Postdoctoral Research Fellow in tumor cell biology

Postdoctoral Research Fellow in tumor cell biology

A 100% 3-year Postdoctoral Research Fellow position in tumor cell biology is available in the research group of Prof. Philippe Collas, project group of Dr. Marie Rogne, at the Department of Molecular Medicine, Division of Biochemistry, Institute of Basic Medical Sciences, University of Oslo ( Collas Lab ). The position is funded through the Norwegian Cancer Society.

Within the Institute, the Division of Biochemistry consists of a young and active community of nine research groups working on cancer biology, chromatin and nuclear dynamics, nuclear architecture, membrane trafficking, and adipocyte, muscle and vascular biology, using human, fly and mouse models.

More about the position

The overall goal of the project is to establish knowledge of the innovative therapeutic potential of microproteins in advanced prostate cancer. In this context, the successful applicant will, in collaboration with the research team and external partners at Oslo University Hospital, examine how specific microproteins regulate the activity of the transcription factor RUNX2, using cancer cell lines and PDX mouse tumor models, for various cell-based assays. The work involves in vivo setups and is expected to necessitate optimizations.

A postdoctoral position is intended for the employee to develop a research profile and competence that qualifies them to apply for an Associate Professor position. The position may also provide other competencies relevant to the postdoctoral fellow's future career.

A career plan shall be developed for the Postdoctoral Fellow, specifying the competencies the Postdoctoral Fellow should acquire. UiO is responsible for following up on the career plan and ensuring that the Postdoctoral Fellow has access to career guidance throughout the postdoctoral term.

Responsibilities

• Design and execute PDX prostate cancer studies evaluating the effect of microprotein modulation and peptide therapy, using cell biological approaches.
• Design and perform cellular assays to test microprotein function and transcription factor modulation.
• Maintain accurate electronic lab records and contribute to data analysis and interpretation.
• Present results at group meetings and scientific platforms and prepare manuscripts for publication.

Qualifications

Qualification requirements

• Applicants must hold a doctoral degree – PhD or equivalent.
• If a doctoral degree is not yet awarded, the doctoral dissertation must be submitted for evaluation by the closing application date. Hiring will however be contingent on obtention of a doctoral degree.
• Solid knowledge of, and experience in, (cancer) cell biology.
• Experience in tumor biology.
• Experience with cell culture and/or patient-derived xenograft (PDX) tumor models.
• Fluent oral and written communication skills in English.

RelevantQualifications

• Experience with molecular biology and/or epigenetics is positive.
• Authorization to work with laboratory animals (rodents) (e.g. LAS301, FELASA C) is a strong advantage.If you do not have such authorization, you will be required to acquire it in the first part of your employment.
• Experience with electronic lab-journal systems (e.g. Benchling or E-lab) is valued.

Personal skills

• You are independent but enjoy working as part of a team towards shared, ambitious goals.
• You are positive, structured, solution-driven and accurate, with grit and determination.
• You have a result-oriented mindset and contribute scientific and practical inputs.
• Communication with other team members is important: you will therefore have excellent communication and collaborative skills.

Employment in the position is based on a comprehensive assessment of all qualification requirements applicable to the position, including personal qualifications.

Jarli & Jordan / UiO

We need different perspectives in our work

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