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PhD fellowship in cancer research
2 weeks ago
Om stillingen
Oslo University Hospital
Oslo University Hospital is Norway's largest hospital with over employees. It is the local hospital for most of Oslo's population and has highly specialized care at a national level. The Department of Pathology is one out of seven departments within the Division of Laboratory medicine. It is the largest pathology department in Norway, with over 300 employees. The Department has a strong research section that is organized in seven research groups. Current research topics address cancer, immunopathology, inflammation and neurodegenerative diseases.
Oslo University Hospital is a workplace with great diversity. We believe this is crucial for solving our tasks in the best possible way. We want this diversity to be reflected among the applicants for our positions, and we encourage all qualified candidates, regardless of background, to apply
Nøkkelinformasjon
Søknadsfrist:
Arbeidsgiver:
Oslo universitetssykehus HF
Sted:
Oslo
Stillingstittel:
PhD fellowship
Stillinger:
1
Heltid / Deltid:
Heltid
Ansettelsesform:
Utdanningsstilling
Stillingsprosent:
100
Webcruiter-ID:
Sosial deling :
Del på X
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Del på e-post
About the position
The position is available from May 1st 2026, but both a later and earlier startup date is possible. Dr. Håvard Lindholm is principal investigator of the study. The position will be located in the laboratory of Professor Frode Jahnsen ) at in the Department of Pathology at Oslo University Hopsital, Rikshospitalet.
This is a collaborative project between the Jahnsen team, the group of professor Hege Elisabeth Giercksky Russnes at Oslo University Hospital and the group of Professor Daniel De Carvalho at Princess Marget Cancer Centre in Toronto, Canada. All research groups are internationally leading experts in immunology, cancer, and bioinformatics.
The project aims to explore how antiviral defense pathways can be harnessed to kill breast cancer cells. Breast cancer is the most common form of cancer in women and novel therapies are needed to improve disease outcomes. We will sequence RNA from a cohort of more than 300 breast cancer patients, explore the activation mechanism of antiviral defense pathways in cell cultures and perform bioinformatics analysis of data. The work will be performed in a modern molecular biology lab with access to specialized equipment such as a P2 solo instrument which will be used to perform Oxford Nanopore Sequencing on site. We also have access to computational clusters which can be used for analysis.
Antiviral defense pathways can be activated if double stranded RNA (dsRNA) is expressed from our own genome. Normally, dsRNA is only present in a human cell infected with viruses and human cells have innate immune receptors that can recognize dsRNA. However, pathways dysregulated in cancer can lead to expression of repeated elements forming dsRNA. This would lead to the activation of antiviral defenses which can kill the cancer cell. Through the analysis in this project, we will hopefully understand when and where this dsRNA is expressed in cancer and how to target it for future cancer therapeutics.
For more details see this review:
Please get in touch if you don't have access to the review.
The candidate will:
Perform Oxford Nanopore sequencing of RNA samples from breast cancer patients.
Do wet lab experiments exploring mechanisms regulating the fate of dsRNA in cells.
Create scripts to analyze the output of experiments.
Perform bioinformatic analysis of publicly available data.
Wet lab experiments are an important part of the project, but they will mostly generate large datasets requiring bioinformatic analysis. Lack of experience with wet lab or bioinformatics can be accepted if the candidate has good experience in just one of the two. The principal investigator, and the rest of the team, have extensive experience in both molecular biology and bioinformatics and will provide necessary training.
The ideal candidate should meet the following criteria:
Applicants must hold an MsC degree in biology, immunology, medicine, bioinformatics, computational biology, informatics or a related field.
Experience in molecular biology techniques. Experience with library preparation, cell culture and/or synthesis of RNA is a plus.
Experience in bioinformatics. Knowledge of Python and analysis of sequencing data is a plus.
Fluent oral and written communication skills in English.
We are looking for a highly motivated candidate who is interested in identifying and addressing important scientific problems.
The application must include:
Application letter describing the applicant's qualifications and motivation for the position
CV (summarizing education, positions, and academic work)
MsC thesis
Copies of educational certificates and transcript of records
Letters of recommendation or names and contact details of 2-3 references (name, relation to candidate, e-mail and telephone number)
The application with attachments must be delivered in our electronic recruiting system, please follow the links "apply for this job". Foreign applicants are advised to attach an explanation of their University's grading system. Please note that all documents should be in English (or a Scandinavian language). Applicants invited for an interview are asked to provide educational certificates, diploma or transcript of records.
Adresse:
Sognsvannsveien 20, 0372 Oslo, Norge
Åpne veibeskrivelse
(i ny fane)
Kontaktinformasjon
Håvard Takle Lindholm
Postdoctor
Telefon:
E-post:
Om arbeidsgiveren
Sammen med pasienten utvikler vi morgendagens behandling
Oslo universitetssykehus med våre medarbeidere skal være en lærende og skapende organisasjon med evne til å tenke nytt. Vi skal ha en ledende rolle i utvikling av forskning og innovasjon, samt utvikling av morgendagens helsetjeneste, medisinsk behandling og presisjonsmedisin. Hos oss finner du noen av landets ledende eksperter innen sine fagfelt, og her blir du en del av Norges største helsefaglige arbeidsplass. Et inkluderende arbeidsmiljø preget av åpenhet og respekt er svært viktig for oss. Uansett hva du jobber med vil du få muligheten til å utvikle deg og benytte din kompetanse på et sted hvor det virkelig teller.
