Researcher in Computational Genomics

23 hours ago


Oslo, Oslo County, Norway Byggmakker Norge AS Full time

At Byggmakker Norge AS, we are seeking a highly motivated researcher to join our team as part of the project "Targeting Epigenetic Dysregulation in Sarcoma". This three-year position is funded by the Norwegian Cancer Society and will be based at the Division of Biochemistry, Institute of Basic Medical Sciences (Department of Molecular Medicine), University of Oslo, Norway.

About the Project

Sarcomas are a heterogeneous group of mesenchymal soft tissue and bone cancers comprising 1% of adult malignancies. Emerging research suggests that a combination of genetic and epigenetic events can drive the onset and progression of tumours. However, the understanding of the specific epigenetic events responsible for driving and sustaining Sarcomas remains incomplete. Our aim is to identify Sarcoma weaknesses by combining knowledge about genetic alterations and epigenetic aberrations to enable the identification of novel cancer targets.

We use genetic, pharmacological, biochemical, single-cell, and genome-wide approaches to elucidate these mechanisms in Sarcomas. This project will specifically rely on high throughput and long-read sequencing of genomic DNA and RNA, single-cell multiomics, and epigenetic techniques such as ChIP-seq, ATAC-seq, and Hi-C. We also perform chemical drug and genome-wide CRISPR screens to identify novel sarcoma targets. The candidate will be responsible for computational analysis to better understand biological features in Sarcomas.

Data integration combined with algorithm development is a potent strategy to create novel models that can be tested experimentally, improving our understanding of complex mechanisms promoting tumorigenesis.



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