Biotech Leader

We are seeking a highly experienced and inspiring leader to join our Discovery team in driving the development of cutting-edge radioligand therapies for the treatment of solid tumors. As a key member of our leadership team, you will oversee the design of translational strategies and collaborate closely with cross-functional teams, including Research, CMC, Clinical Development, and Regulatory Affairs, as well as external CROs to ensure their seamless implementation into our clinical trials.

You will leverage your scientific expertise and a thorough understanding of drug development to lead our team and shape our mission to bring radioligand therapies (RLT) to patients. Your responsibilities will include:

• Building and leading the Preclinical organization, including preclinical imaging, efficacy & safety, bioanalysis, translational biomarker strategy, toxicology, and quantitative pharmacology through a strategic combination of internal experience, external consultants, and CROs to achieve program and organizational goals while balancing resources.
• Responsible for all EHS efforts for ARTO site as well as site agenda and resourcing prioritization.
• Providing leadership, guidance, and mentorship to direct reports or team members, fostering a collaborative environment that encourages professional growth and development.
• Developing IND/CTA-enabling preclinical data packages including non-GLP and GLP pharmacology, toxicology, pharmacokinetic/toxicokinetic studies to support project advancement to and through clinical development.
• Collaborating with Clinical, Tech Ops and CMC groups to augment IND-enabling packages and translational plans for promising preclinical programs.
• Providing strategic direction and oversight of the integrated translational science strategy for all pipeline programs to guide indication/patient selection, pharmacodynamic biomarker strategies, dose/schedule optimization and facilitate data-based decision making to inform and accelerate development.
• Contributing to the authoring of relevant sections of clinical and regulatory documents, including briefing books, IND/CTAs, protocols and IBs.
• Providing tactical support to a multidisciplinary matrixed team executing translational activities across clinical programs, manage timelines and deliverables.
• Identifying and leading the evaluation, validation, and implementation of biomarker and pharmacodynamic assays at CROs for clinical use.

To be successful in this role, you will need to have:

• A PhD or MD in a relevant scientific discipline (e.g. oncology, cell biology) with 12+ years of relevant experience in both small and larger pharmaceutical/biotech industry working with multi-/ cross-functional teams.
• Experience with direct line supervision of multidisciplinary teams (10+).
• A track record of Development Candidate nomination(s) and R&D from LO through to IND/FIH.
• Proven experience in developing and implementing biomarker strategies, including assay development, validation, and data analysis for oncology programs.
• Strong interpersonal and problem-solving skills.
• Capable of successfully planning, coordinating, and monitoring multiple projects.
• Outstanding presentation and communication skills with the ability to grasp the big picture and influence to achieve desired outcome.

About Us

ARTBIO is a clinical-stage radiopharmaceutical company redefining cancer care by creating a new class of alpha radioligand therapies (ARTs). The unique ARTBIO approach selects the optimal alpha-precursor isotope (212Pb) and tumor-specific targets to create therapeutics with the potential for highest efficacy and safety. Our AlphaDirectTM technology enables a distributed manufacturing approach for the reliable production and delivery of ARTs. We are advancing multiple pipeline programs with lead program AB001 currently in first-in-human trials.

Our team takes advantage of diverse scientific depth and insights which makes ARTBIO a unique place to work. We are driven by a desire to do better for cancer patients, lowering the burden of toleration and safety while at the same time raising the bar on clinical efficacy and duration.

Estimated Salary: $250,000 - $350,000 per year based on industry standards and location.