Postdoctoral Fellow in bile duct immunology
2 weeks ago
Want to advance understanding of bile duct inflammation with integrated multiomics techniques?
A 3-year postdoctoral fellow position is available at the Research Institute of Internal Medicine and the Norwegian PSC Research Center (NoPSC) at Oslo University Hospital. The project is funded by the Research Council of Norway FRIPRO project 4DINFLAMMABILE.
NoPSC is dedicated to research on the chronic liver disease known as primary sclerosing cholangitis (PSC). The NoPSC center comprises three research groups covering all aspects of research related to primary sclerosing cholangitis, from basic genomic and experimental studies to clinical research and clinical trials. The research environment is world-leading for PSC and includes 30-35 engaged researchers from several countries and specialties.
The immune system plays a clear role in the pathogenesis of PSC, but the specific inflammatory mechanisms leading to the destruction of the bile ducts remain unknown.
We invite highly motivated candidates with an interest in liver disease, immunology, and multiomic methodologies (sequencing-based and protein phenotyping) to apply for the postdoctoral position.
The postdoc will participate in the ongoing 4DINFLAMMABILE project, which aims to characterize bile duct inflammation in order to identify targetable molecular pathways using a range of multiomic techniques. In-depth characterization of animal models of bile duct inflammation and patients with PSC has been performed using spatial transcriptomics and single-cell sequencing (10x Genomics), mainly focusing on liver tissue.
ResponsibilitiesOur new colleague will take on the challenging task of extending transcriptomic findings to the protein level using various state-of-the-art staining techniques, such as tissue CyTOF, CLARITY, and single-cell/spatial proteomics. A key task will also be to integrate sequencing-based datasets with proteomics, in collaboration with our bioinformaticians.
The duration of appointment is 3 years.
QualificationsRequired selection criteria
- A degree equivalent to a Norwegian doctoral degree in molecular biology or immunology. The doctoral dissertation must be submitted for evaluation by the closing date. Appointment is dependent on the approval of the public defense of the doctoral thesis.
- The ability to design, plan, and interpret original experiments in an independent and innovative way.
- Experience with sequencing-based methods for immunological characterization.
- Fluent oral and written communication skills in English.
Preferred selection criteria
- A strong background in imaging techniques and proteomics.
- Fluent oral and written communication skills in a Scandinavian language.
- Well organized with high working capacity and productivity.
- Excellent team working skills.
- Strong motivation for a career in science, including project management and scientific writing.
Employment in the position is based on a comprehensive assessment of all qualification requirements applicable to the position, including personal qualifications.
We offer- Exciting and meaningful tasks in an organization with an important societal mission, contributing to knowledge development, education, and enlightenment that promote sustainable, fair, and knowledge-based societal development.
- Committed colleagues in a good working environment.
- A workplace with good development and career opportunities.
- Membership in the Statens Pensjonskasse, which is one of Norway's best pension schemes with beneficial mortgages and good insurance schemes.
- Salary in position as Postdoctoral Fellow, position code 1352 in salary range NOK from 595 000 - 658 000, depending on competence and experience. Higher salary can be offered to particularly qualified candidates. From the salary, 2 percent is deducted in statutory contributions to the State Pension Fund.
Your application should include:
- CV.
- A complete list of publications.
- Transcripts and certificates.
- Contact information for 2-3 references.
Application with attachments must be submitted via our recruitment system Jobbnorge, click "Apply for the position". When applying for the position, we ask you to retrieve your education results from Vitnemålsportalen.no. If your education results are not available through Vitnemålsportalen, we ask you to upload copies of your transcripts or grades. Please note that all documentation must be in English or a Scandinavian language.
General informationThe best qualified candidates will be invited for interviews. Applicant lists can be published in accordance with Norwegian Freedom of Information Act § 25. When you apply for a position with us, your name will appear on the public applicant list. It is possible to request to be excluded from this list. You must justify why you want an exemption from publication and we will then decide whether we can grant your request. If we can't, you will hear from us.
University of OsloThe University of Oslo is Norway's oldest and highest ranked educational and research institution, with 28 000 students and 7000 employees. With its broad range of academic disciplines and internationally recognised research communities, UiO is an important contributor to society.
The Institute of Clinical Medicine (Klinmed) is one of three institutes under the Faculty. Klinmed is responsible for the Faculty's educational and research activities at Oslo University Hospital and Akershus University Hospital. With about 900 employees spread over approximately 425 man-labour years, Klinmed is the university's largest institute. Our activities follow the clinical activity at the hospitals and are spread across a number of geographical areas.
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