Researcher in Computational Oncology

3 days ago


Oslo, Oslo County, Norway Byggmakker Norge AS Full time

A 2-year Researcher position is available in the Computational Biology and Systems Medicine group led by Marieke Kuijjer at the Centre for Molecular Medicine Norway (NCMM), Faculty of Medicine, University of Oslo, Nordic EMBL partner (see here for more information).

The group was established in 2018 and focuses on using computational approaches to understand the molecular mechanisms that drive cancer development, progression, and heterogeneity. The group's driving hypothesis is that the complex clinical phenotypes we observe in cancer cannot be adequately defined by individual layers of molecular data. Instead, we must consider the underlying network of interactions between the different biological components that can drive cancer phenotypes. To do so, the group develops computational approaches that place genomic data into the context of large-scale, genome-wide regulatory networks, as well as approaches to analyze such networks for individual cancer patients.

Amongst others, our current projects aim at developing new computational methods and tools for:

  1. Modeling enhancer-promoter interactions,
  2. Integration of multi-modal single cell data using deep learning,
  3. Fine-tuned analysis of genome-wide regulatory networks,
  4. Integration of patient-specific regulatory networks with multi-omic data,
  5. Modeling networks based on single cell and spatial transcriptomic data.

See also here for more information.

The candidate

We seek a highly motivated candidate with a track record of computational tool development dedicated to the modeling and analysis of genome-wide gene regulatory networks. The candidate should be excited about developing and applying computational tools to answer questions in biology. The ideal candidate is collaborative and creative, has strong programming skills dedicated to the analysis of large-scale genomics data, and a strong publication record. Experience with analysis of large-scale genomic data sets, network analysis, and computational tool development are requirements for this position. Experience with data integration, cancer biology, and gene regulation is considered an advantage. The position is open to applicants with a PhD in computational fields, such as computational biology, bioinformatics, or biostatistics.

The candidate will be developing computational tools for gene regulatory network modeling and analysis using single-cell and spatial omics data, with applications to study breast cancer metastasis.

The appointment is a fulltime position and is made for a period of two years.

Qualification requirements
  • PhD degree in computational biology, bioinformatics, biostatistics, or a related field with computational focus
  • Minimum of two years of completed postdoctoral training is required for this position
  • Strong publication record (including 1st authorship) with evidence of writing scientific manuscripts independently
  • Proficiency in programming (such as R, Python, MATLAB, Bash)
  • Documented experience with computational tool development dedicated to the modeling and analysis of genome-wide gene regulatory networks
  • Knowledge in gene regulation, cancer, and/or data integration is considered an advantage
  • Experience with high performance computing is desirable
  • Professional proficiency in English
  • Willingness to work in a team environment, sharing skills and ideas, and collaborating on projects
  • High drive for science and desire to become an independent researcher
  • Fluent oral and written communication skills in English
We offer
  • A professional, stimulating working environment
  • A workplace with good development and career opportunities.
  • Membership in the Statens Pensjonskasse, which is one of Norway's best pension schemes with beneficial mortgages and good insurance schemes.
  • Salary in position as Researcher, position code 1109 in salary range from NOK 590000-700000, depending on competence and experience. From the salary, 2 percent is deducted in statutory contributions to the State Pension Fund.
How to apply

The application, including attachments, must be delivered through the electronic recruiting system. The application must include:

  1. A cover letter that briefly highlights your motivation, scientific background, and research interests (maximum 1 page)
  2. A detailed CV with a list of publications
  3. 2-3 references (name, institution, e-mail, telephone number, and relation to the candidate)

Application with attachments must be submitted via our recruitment system Jobbnorge, click "Apply for the position". These should be uploaded in .pdf format. While the recruitment system includes a basic CV, we ask candidates to also include a separate, detailed CV as well as cover letter in .pdf format with their application. Applications without a cover letter and/or detailed CV in this format will be rejected.

General information

The best qualified candidates will be invited for interviews.

Applicant lists can be published in accordance with Norwegian Freedom of Information Act § 25. When you apply for a position with us, your name will appear on the public applicant list. It is possible to request to be excluded from this list. You must justify why you want an exemption from publication and we will then decide whether we can grant your request. If we can't, you will hear from us.

The University of Oslo has a transfer agreement with all employees that is intended to secure the rights to all research results etc.

Contact information

Inquiries about the position can be directed to Marieke Kuijjer, marieke.kuijjer@ncmbm.uio.no. For questions relating to the administrative aspects of the application, please contact Nina Modahl, ninam@ncmbm.uio.no.

University of Oslo

The University of Oslo is Norway's oldest and highest ranked educational and research institution, with 28,000 students and 7,500 employees. With its broad range of academic disciplines and internationally recognised research communities, UiO is an important contributor to society.

Centre for Molecular Medicine Norway (NCMM) was established in 2008 and is the Norwegian node in the Nordic EMBL Partnership for Molecular Medicine. NCMM is a joint venture between the University of Oslo, Health Region South-East and the Research Council of Norway. From 2017 NCMM is merged with the Biotechnology Centre of Oslo and now has altogether 11 research groups. The overall objective of NCMM is to conduct cutting edge research in molecular medicine and biotechnology as well as facilitate translation of discoveries in basic medical research into clinical practice.

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