Senior Radiobiology Expert

2 days ago

Oslo, Oslo County, Norway Work In Biotech Full time
About the Role
We are seeking a highly motivated Senior Scientist to join our Translational Biology team in Radioligand Therapy development. As a key member of our team, you will play a critical part in advancing our innovative pipeline of targeted radiotherapies designed to revolutionize cancer treatment.

Responsibilities
  • Manage and execute in-vitro radiobiology studies to enable development of novel radioligand candidates from early Discovery to IND-readiness according to the company's strategy.
  • Design and execute radiolabelling and analytical characterisation of radioligands and assessment of quality in close collaboration with the in-vitro radiochemistry team.
  • Interface with project team and leadership to lead project goals and experimental design for drug development.
  • Collaborate with external vendors and academic facilities for sourcing of reagents and execution of experimental activities.
  • Provide mentorship and supervision to other preclinical team members so that experiments and projects are performed according to plan and internal ways of working.
  • Support writing of regulatory documentation related to pre-clinical studies for RLT candidates selected for clinical development.
  • Provide deep scientific expertise to guide selection of novel targets, candidate molecules and best experimental approaches to address relevant scientific questions.
  • Develop innovative solutions to mitigate research challenges & increase throughput and processes efficiency.
  • Oversee data collection, analysis, interpretation, reporting and presentation.
  • Multitask and collaborate effectively with other scientists and research associates to accomplish goals on tight timelines.
  • Maintain compliance with lab documentation to enable collaboration among multinational project teams.

Qualifications & Education
  • PhD or equivalent degree in Molecular Biology, Radioligand therapy development, Radiation Biology or other relevant discipline with significant laboratory-based skills component.
  • At least 5 years working in research projects, particularly in drug discovery and in vitro testing of novel radioligands.
  • Preferred industry experience, preferably radioligand therapy or oncology.
  • Good English speaking and writing skills.
  • Critical understanding of principles of receptor pharmacology theory and experimental methodologies to assess ligand binding.
  • Specific experience with radioligand therapy development, including radiolabelling and radiopharmaceutical applications.
  • Proficiency in radiation safety practices and regulations, including working with open sources and radionuclides.
  • Proven ability to develop, optimize, and validate novel in-vitro methods and techniques and creating and implementing high throughput screening methods to streamline research processes.
  • Experience with Analytical Techniques such as gamma counters, Germanium Detectors, dose calibrators, Thin Layer Chromatography and High-Performance Liquid Chromatography is a plus.
  • Conducting and interpreting internalization assays to understand cellular uptake of radioligands.
  • Strong analytical skills for processing and interpreting complex experimental data.
  • Ability to work effectively within interdisciplinary teams and contribute to collaborative research efforts.
  • Excellent communication skills for writing reports, preparing presentations, and publishing research findings.
  • Experience managing research projects, timelines, and resources.
  • Line management experience, including supervising and mentoring junior scientists.
  • Demonstrated problem-solving abilities and innovation in addressing research challenges.

About Us
ARTBIO is a clinical-stage radiopharmaceutical company redefining cancer care by creating a new class of alpha radioligand therapies (ARTs). The unique ARTBIO approach selects the optimal alpha-precursor isotope (212Pb) and tumor-specific targets to create therapeutics with the potential for highest efficacy and safety. The company's AlphaDirectTM technology, a first-of-its-kind 212Pb isolation method, enables a distributed manufacturing approach for the reliable production and delivery of ARTs. ARTBIO is advancing multiple pipeline programs with lead program AB001 currently in first in human trials. ARTBIO is shaped by a long-standing scientific legacy with nearly a century of pioneering work in radiation therapy conducted at the University of Oslo and Norway's Radium Hospital. For more information, visit www.artbio.com, and follow us on LinkedIn and Twitter.

As an emerging, global biotech with locations in Boston, Massachusetts, Basel, Switzerland, London, England and Oslo, Norway, we take advantage of diverse scientific depth and insights which makes ARTBIO a unique place to work. We are driven by a desire to do better for cancer patients, lowering the burden of toleration and safety while at the same time raising the bar on clinical efficacy and duration.

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