Researcher in human pregnancy genomics/epidemiology
24 hours ago
Reference number PAR 2024/1175
The University of Gothenburg tackles society's challenges with diverse knowledge. 56,000 students and 6,600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract researchers and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.
The Institute of Clinical Sciences, Obstetrics and Gynecology at Sahlgrenska Academy, is seeking a researcher for perinatal medical dry lab research at the Perinatal laboratory. The Perinatal laboratory is a research laboratory with extensive research activity of a high international level. The main languages are English and Swedish, and the working environment is stimulating and developing with high productivity. The research group is inter-professional.
The Perinatal laboratory and research group is led by Professor Bo Jacobsson. Our research group is located at the University of Gothenburg in Sweden and the Norwegian Institute of Public Health (Oslo). We investigate genetic and environmental factors affecting human gestational age at preterm birth. We work with unique genomic data containing thousands of family trios from Norway, complemented by extensive collections of medical and questionnaire-related variables, validated environmental exposures, and a birth registry covering over four million pregnancies from Sweden.
Preterm delivery and the duration of gestation are heritable traits. Our group has recently published the largest GWAS meta-analysis of gestational duration and preterm birth to date. The researcher will contribute to ongoing efforts in this field (GWAS, meta-analyses, gene-environment interactions, etc.) and to dive deeper into the known genetic variants affecting the duration of gestation and preterm delivery. We expect to expand the analyses conducted in our previous work to diverse ancestries and to sub-phenotypes of preterm delivery.
DutiesThe main task is to conduct high-quality research in perinatal medical research. There will be great opportunities to expand focus within the framework of the specified projects and the researcher's interests. The applicant is expected to be able to contribute to other projects (from collaborators or other researchers at PerinatalLab).
Your responsibilities will include working on GWAS, meta-analyses, and gene-environment interactions, as well as analyzing genetic variants influencing pregnancy duration and preterm birth. You will work with unique datasets, including genotypic and phenotypic data from the Mother, Father, and Child cohort (over 40,000 trios), ALSPAC (~6,000 mother-child pairs), and HUNT, providing access to genetic data from 350,000 individuals linked to extensive phenotypic datasets.
The tasks include data acquisition, quality control and analysis, dissemination of results, and supervision of master and doctoral students. Furthermore, the researcher is expected to contribute to high impact level publications.
The position involves taking significant responsibility for various types of important administrative work for the PI and the needs of the whole group related to academic research, such as grant applications, writing scientific reports and project proposals, writing ethics applications, as well as co-authoring research manuscripts, including submission to the journal process and other tasks.
QualificationsTo be eligible for the position, you must hold a doctoral degree in a relevant field, such as molecular biology, statistical biology, biomedical science, epidemiology, genetics, statistics, mathematics, or computer science. Experience in statistical modeling, either in the context of genetics or epidemiology, as well as the ability to work in R/Python and a UNIX environment are required.
Other qualifications include excellent oral and written English language skills, proven ability to write coherent scientific text with at least one published or submitted manuscript where the applicant is the first author and wrote a major part of the text. The position requires collaboration with colleagues and other research groups, but the ability to generate and pursue research ideas independently will be essential. Fluency in Swedish is also a merit.
Advantages are:
- Experience with population genetics (microarrays, GWAS, GxE studies)
- Experience with large data analysis or bioinformatics
- Clinical knowledge of physiology and biology of pregnancy (gestation, preterm birth, fetal growth, preeclampsia, inflammation, infection)
- Experience in molecular biology (control of gene expression)
- Experience with epidemiological studies
- Experience in student supervision
- Experience with version control in Git
The employment is a permanent position, full time and placed at the Institute of Clinical Science, department of Obstetrics and Gynecology. A probationary period may apply. First day of employment as agreed.
Contact information for the postIf you have questions regarding the position, please contact Professor Bo Jacobsson via Unit manager Ylva Folkesson at e-mail: ylva.folkesson@vgregion.se or Co-PI Pol Solé Navais at e-mail: pol.sole.navais@gu.se.
To apply for a position at the University of Gothenburg, you have to create an account in our recruitment system. Your application must include:
- Proof of doctoral degree
Submit your application via the University of Gothenburg's recruitment portal by clicking the "Apply" button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline.
Applications must be received by: 2025-01-29
The University works actively to achieve a working environment with equal conditions and values the qualities that diversity brings to its operations.
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