Senior Director/Vice President, Preclinical Research

4 weeks ago

Oslo, Oslo County, Norway Work In Biotech Full time
Job Summary
We are seeking an experienced leader to drive the development of cutting-edge radioligand therapies for the treatment of solid tumors. As a key member of our Discovery team, you will oversee the design of translational strategies and collaborate closely with cross-functional teams to ensure seamless implementation into our clinical trials.

We are looking for someone who thrives in a fast-paced environment that rewards curiosity, humility, and adaptability. You will leverage your scientific expertise and a thorough understanding of drug development to lead our team and shape our mission to bring Radioligand therapies (RLT) to patients.

Key Responsibilities:
  • Build and lead the Preclinical organization, including preclinical imaging, efficacy & safety, bioanalysis, translational biomarker strategy, toxicology, and quantitative pharmacology through a strategic combination of internal experience, external consultants, and CROs to achieve program and organizational goals while balancing resources
  • Responsible for all EHS efforts for our site as well as site agenda and resourcing prioritization
  • Provide leadership, guidance, and mentorship to direct reports or team members, fostering a collaborative environment that encourages professional growth and development
  • Develop IND/CTA-enabling preclinical data packages including non-GLP and GLP pharmacology, toxicology, pharmacokinetic/toxicokinetic studies to support project advancement to and through clinical development
  • Collaborate with Clinical, Tech Ops, and CMC groups to augment IND-enabling packages and translational plans for promising preclinical programs
  • Provide strategic direction and oversight of the integrated translational science strategy for all pipeline programs to guide indication/patient selection, pharmacodynamic biomarker strategies, dose/schedule optimization, and facilitate data-based decision making to inform and accelerate development
  • Contribute to the authoring of relevant sections of clinical and regulatory documents, including briefing books, IND/CTAs, protocols, and IBs
  • Provide tactical support to a multidisciplinary matrixed team executing translational activities across clinical programs, manage timelines, and deliverables
  • Identify and lead the evaluation, validation, and implementation of biomarker and pharmacodynamic assays at CROs for clinical use
Requirements
  • PhD or MD in a relevant scientific discipline (e.g. oncology, cell biology) with 12+ years of relevant experience in both small and larger pharmaceutical/biotech industry working with multi-/cross-functional teams
  • Experience with direct line supervision of multidisciplinary teams (10+)
  • Track record of Development Candidate nomination(s) and R&D from LO through to IND/FIH
  • Proven experience in developing and implementing biomarker strategies, including assay development, validation, and data analysis for oncology programs
  • Strong interpersonal and problem-solving skills
  • Capable of successfully planning, coordinating, and monitoring multiple projects
  • Outstanding presentation and communication skills with the ability to grasp the big picture and influence to achieve desired outcome
About Us
Our company is a clinical-stage radiopharmaceutical company redefining cancer care by creating a new class of alpha radioligand therapies (ARTs). Our unique approach selects the optimal alpha-precursor isotope (212Pb) and tumor-specific targets to create therapeutics with the potential for highest efficacy and safety. Our AlphaDirectTM technology, a first-of-its-kind 212Pb isolation method, enables a distributed manufacturing approach for the reliable production and delivery of ARTs. We are advancing multiple pipeline programs with lead program AB001 currently in first-in-human trials. We are shaped by a long-standing scientific legacy with nearly a century of pioneering work in radiation therapy conducted at the University of Oslo and Norway's Radium Hospital. For more information, visit www.artbio.com, and follow us on LinkedIn and Twitter.

We are an emerging, global biotech with locations in Boston, Massachusetts, Basel, Switzerland, London, England, and Oslo, Norway. We take advantage of diverse scientific depth and insights, making us a unique place to work. We are driven by a desire to do better for cancer patients, lowering the burden of toleration and safety while raising the bar on clinical efficacy and duration.

EEO Statement
We are proud to be an equal opportunity workplace and an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, or Veteran status. If you have a disability or special need that requires accommodation, please let us know.

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